Cutting Edge: Protective Response to Pulmonary Injury Requires gd T Lymphocytes

Antigen by N-End Rule Targeting of a Model Tumor Vivo CTL-Dependent Protective Immunity In Cutting Edge: Induction of Enhanced

Cutting Edge: IFN-gamma-producing CD4 T lymphocytes mediate spore-induced immunity to capsulated Bacillus anthracis.

Virulent strains of Bacillus anthracis produce immunomodulating toxins and an antiphagocytic capsule. The toxin component-protective Ag is a key target of the antianthrax immune response that induces production of toxin-neutralizing Abs. Coimmunization with spores enhances the antitoxin vaccine, and inactivated spores alone confer measurable protection. We aimed to identify the mechanisms of pr...

Cutting edge: Protective effect of CX3CR1+ dendritic cells in a vaccinia virus pulmonary infection model.

The protective host immune response to viral infections requires both effective innate and adaptive immune responses. Cross-talk between the two responses is coordinated by the chemokine network and professional APCs such as dendritic cells (DCs). In mice, subpopulations of myeloid DCs in peripheral tissues such as lungs and in blood express CX3CR1 depending on the inflammation state. We thus e...

T Lymphocytes Contributes to Optimal Inducibility in Activated Element in the CD95 Ligand Promoter Cutting Edge: A Newly Identified Response

Cutting Edge: Generation of Colitogenic Th17 CD4 T Cells Is Enhanced by IL-17 gd T Cells